The role of breastfeeding in improving the immune system and preventing respiratory infections in children

Authors

DOI:

10.52832/jesh.v5i3.551

Keywords:

Breastfeeding, Respiratory tract diseases, Adaptive immunity

Abstract

The study sought to verify evidence that proves the benefits of breastfeeding in immunological protection and in the prevention of respiratory infections in children, highlighting its main bioactive components. Integrative literature review carried out in the National Library of Medicine (PubMed), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Latin American and Caribbean Literature in Health Sciences (LILACS) databases in November 2024. Articles published in English, Portuguese and Spanish, from 2019 to 2024, were included. The search used the following Health Sciences Descriptors (DeCs): “Breast Feeding”, “Respiratory Tract Infections”, “Infant”, combined by AND. A total of 101 studies were identified, evaluated by titles, abstracts and full reading, selecting, in the end, 07 articles. Early and exclusive breastfeeding plays a crucial role in preventing respiratory diseases such as bronchiolitis, pneumonia, SARS-CoV-2 and asthma, due to the immunological components of breast milk, such as immunoglobulins, lactoferrin and oligosaccharides. In addition, it contributes to reducing the need for hospitalizations and medical interventions. Exclusive breastfeeding significantly strengthens the infant's immune system, reducing the risk of respiratory infections and promoting protection against pathogens. The action of the bioactive components of breast milk is essential for the respiratory and immunological health of infants, making breastfeeding an effective strategy for disease prevention.

Downloads

Download data is not yet available.

Author Biographies

Sarah Rebeca Alves de Sousa, Centro Universitário Santa Maria

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Marta Lígia Vieira Melo, CENTRO UNIVERSITÁRIO SANTA MARIA

Mestre em Saúde Coletiva pela Universidade Católica de Santos (UNISANTOS - SP), Graduada em fisioterapia pela Universidade Estadual da Paraíba (UEPB) e Professora dos cursos de Fisioterapia e Medicina do Centro Universitário Santa Maria (UNIFSM), Cajazeiras, Paraíba, Brasil.

 

 

Joaquim Fernandes de Sousa Neto, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Isaac Lucca Bezerra Alves Lourenço Gomes, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Rita de Kássia Azevedo Alves, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Beatriz Potyguara Wanderley Martins, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Maria Alice Vieira Melo de Lima , CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Maria Eduarda Bezerra Daltro, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Eryclys Abreu Lira, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Lohany Custódio Pereira de Carvalho, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

José Lídio da Silva Grangeiro, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Ana Caroline Linhares de Castro, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Álvaro da Silva Oliveira, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

Vitória Vieira de Sales Saraiva, CENTRO UNIVERSITÁRIO SANTA MARIA

Discente do Curso de Medicina do Centro Universitário Santa Maria - UNIFSM, BR 230 Km 504, Cajazeiras-PB.

References

Ames, S. R., Lotoski, L. C., & Azad, M. B. (2023). Comparing early life nutritional sources and human milk feeding practices: personalized and dynamic nutrition supports infant gut microbiome development and immune system maturation. Gut Microbes, 15(1), 2190305. https://doi.org/10.1080/19490976.2023.2190305

Ayse Agac, Kolbe, S., Ludlow, M., Albert, Meineke, R., & Rimmelzwaan, G. F. (2023). Host Responses to Respiratory Syncytial Virus Infection. Viruses, 15(10), 1999–1999. https://doi.org/10.3390/v15101999

Barbosa, A. A. M., Silva, D. S. da, Castilho, L. B., Oliveira, M. C. C. de, Zotti, M. E. G., & Faria, F. P. de. (2022). As infecções respiratórias agudas na infância como problema de saúde pública no Brasil. Ciências Biológicas E Da Saúde: Integrando Saberes Em Diferentes Contextos, 70–79. https://doi.org/10.37885/220709304

Bernardes, SI, Macedo, IM, & Távora, PF (2020). A prevalência de infecções respiratórias agudas e seus agentes etiológicos diagnosticados por exames rápidos em público infanto-juvenil de belo horizonte. Revista Interdisciplinar Ciências Médicas, 4 (2), 56–59. https://revista.fcmmg.br/index.php/RICM/article/view/109

Binia, A., Siegwald, L., Sultana, S., Shevlyakova, M., Lefebvre, G., Foata, F., Combremont, S., Charpagne, A., Vidal, K., Sprenger, N., Rahman, M., Palleja, A., Eklund, A. C., Nielsen, H. B., Brüssow, H., Sarker, S. A., & Sakwinska, O. (2021). The Influence of FUT2 and FUT3 Polymorphisms and Nasopharyngeal Microbiome on Respiratory Infections in Breastfed Bangladeshi Infants from the Microbiota and Health Study. MSphere, 6(6). https://doi.org/10.1128/msphere.00686-21

Borg, B., Gribble, K., Courtney-Haag, K., Parajuli, K. R., & Mihrshahi, S. (2022). Association between early initiation of breastfeeding and reduced risk of respiratory infection: Implications for nonseparation of infant and mother in the COVID-19 context. Maternal & Child Nutrition, 18(3). https://doi.org/10.1111/mcn.13328

Daniela, L., & Paulina, V. (2022). Lactancia materna en épocas de covid-19. Más Vita, 130–152. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1372278

Flores, J. A., Coit, J., Mendoza, M., Leon, S. R., Konda, K., Lecca, L., & Franke, M. F. (2021). Is exclusive breastfeeding for six-months protective against pediatric tuberculosis? Global Health Action, 14(1), 1861922. https://doi.org/10.1080/16549716.2020.1861922

Frank, N. M., Lynch, K. F., Uusitalo, U., Yang, J., Lönnrot, M., Virtanen, S. M., Hyöty, H., & Norris, J. M. (2019). The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children. BMC Pediatrics, 19(1). https://doi.org/10.1186/s12887-019-1693-2

Geller, R. J., Inhofe, N. R., Crifase, C. C., Espinola, J. A., Gallegos, C., Herrera, N., Mitri, E., Qi, Y. (Shelly), Sullivan, A. F., & Camargo, C. A. (2023). Case–control study of exclusive breast feeding and severe bronchiolitis in the United States. Paediatric and Perinatal Epidemiology. https://doi.org/10.1111/ppe.12966

Jansen, S., Widya Wasityastuti, Fajar Dwi Astarini, & Sri Hartini. (2020). Mothers’ knowledge of breastfeeding and infant feeding types affect acute respiratory infections. Journal of Preventive Medicine and Hygiene, 61(3), E401–E408. https://doi.org/10.15167/2421-4248/jpmh2020.61.3.1499

Jiménez-Nogueira, E., Bueno-Rebollo, C., García-Jerez, B., Callejón-Fernández, E., Díaz-Torres, M. J., González-Jiménez, Y., Lozano-Paniagua, D., Juárez-Marruecos, P., Nievas-Soriano, B. J., & Bonillo-Perales, A. (2024). Impact of breastfeeding on ICU admissions and need for mechanical ventilation in infants younger than 6 months with RSV+ bronchiolitis. An observational study. Pediatric Pulmonology, 59(10), 2442–2448. https://doi.org/10.1002/ppul.27036

Krishna Kumar Yadav, & Awasthi, S. (2023). Childhood Pneumonia: What’s Unchanged, and What’s New?

https://doi.org/10.1007/s12098-023-04628-3

Lubacheveski, K. M., & Martins, E. L. (2021). A importância da amamentação e os fatores que desencadeiam o desmame precoce: Revisão de Literatura. Revista de Educação, Saúde E Ciências Do Xingu, 1(4). https://periodicos.uepa.br/index.php/rescx/article/view/4208

Machado, A. B. M. e ., Souza, D. L. V. B. de ., Carvalho, M. de S. ., Santos, V. B. ., & Santos, T. P. dos . (2022). O efeito protetor da imunoglobulina A na amamentação exclusiva até os seis meses de vida. Revista Ibero-Americana De Humanidades, Ciências E Educação, 8(12), 428–435. https://doi.org/10.51891/rease.v8i12.7989

Nguyen, P., Binns, C. W., Ha, A. V. V., Chu, T. K., Nguyen, L. C., Duong, D. V., Do, D. V., & Lee, A. H. (2019).

Prelacteal and early formula feeding increase risk of infant hospitalisation: a prospective cohort study. Archives of Disease in Childhood, archdischild-2019-316937. https://doi.org/10.1136/archdischild-2019-316937

Pace, R. M., Williams, J. E., Järvinen, K. M., Belfort, M. B., Pace, C. D. W., Lackey, K. A., Gogel, A. C., Nguyen-Contant, P., Kanagaiah, P., Fitzgerald, T., Ferri, R., Young, B., Rosen-Carole, C., Diaz, N., Meehan, C. L., Caffe, B., Sangster, M. Y., Topham, D., McGuire, M. A., & Seppo, A. (2020). COVID-19 and human milk: SARS-CoV-2, antibodies, and neutralizing capacity. MedRxiv. https://doi.org/10.1101/2020.09.16.20196071

Pang, Z., Hu, R., Tian, L., Lou, F., Chen, Y., Wang, S., He, S., Zhu, S., An, X., Song, L., Liu, F., Tong, Y., & Fan,

H. (2022). Overview of Breastfeeding Under COVID-19 Pandemic. Frontiers in Immunology, 13, 896068. https://doi.org/10.3389/fimmu.2022.896068

Santos, & Emilly Peixoto Meira. (2023). Relação entre aleitamento materno e asma. Bionorte, 12(Suppl.3), 9–15. https://doi.org/10.47822/bn.v12isuppl.3.776

Tachimoto, H., Imanari, E., Mezawa, H., Okuyama, M., Urashima, T., Hirano, D., Gocho, N., & Urashima, M. (2020). Effect of Avoiding Cow’s Milk Formula at Birth on Prevention of Asthma or Recurrent Wheeze Among Young Children. JAMA Network Open, 3(10), e2018534. https://doi.org/10.1001/jamanetworkopen.2020.18534

Tonon, K. M., Chutipongtanate, S., Morrow, A. L., & Newburg, D. S. (2024). Human Milk Oligosaccharides and Respiratory Syncytial Virus Infection in Infants. Advances in Nutrition (Bethesda, Md.), 15(6), 100218. https://doi.org/10.1016/j.advnut.2024.100218

Vassilopoulou, E., Feketea, G., Koumbi, L., Mesiari, C., Berghea, E. C., & Konstantinou, G. N. (2021). Breastfeeding and COVID-19: From Nutrition to Immunity. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.661806

WHO. (2023, December 20). Infant and Young Child Feeding. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/infant-and-young-child-feeding

Wilson, K., Gebretsadik, T., Adgent, M. A., Loftus, C., Karr, C., Moore, P. E., Sathyanarayana, S., Byington, N., Barrett, E., Bush, N., Nguyen, R., Hartman, T. J., LeWinn, K. Z., Calvert, A., Mason, W. A., & Carroll, K. N. (2022). The association between duration of breastfeeding and childhood asthma outcomes. Annals of Allergy, Asthma & Immunology, 129(2), 205–211. https://doi.org/10.1016/j.anai.2022.04.034

Xue, M., Dehaas, E., Chaudhary, N., O’Byrne, P., Satia, I., & Kurmi, O. P. (2021). Breastfeeding and risk of childhood asthma: a systematic review and meta-analysis. ERJ Open Research, 00504-2021. https://doi.org/10.1183/23120541.00504-2021

Yary Maestracci, S. M., Urbaneja Martínez, A. M., YzhacSilva, J. A., Tovar Thomas, C. L., & Pérez de Solórzano, R. J. (2020). Relación entre el tipo de lactancia y la frecuencia de infecciones respiratorias en niños menores de 2 años. Hospital Ruiz y Páez. Ciudad Bolívar-estado Bolívar. Rev. Pediatr. Electrón, 28–38. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1140048

Published

28/08/2025

How to Cite

Alves de Sousa, S. R., Vieira Melo, M. L., Fernandes de Sousa Neto, J., Bezerra Alves Lourenço Gomes, I. L., Azevedo Alves, R. de K., Potyguara Wanderley Martins, B., Vieira Melo de Lima , M. A., Bezerra Daltro, M. E., Abreu Lira, E., Custódio Pereira de Carvalho, L., da Silva Grangeiro, J. L., Linhares de Castro, A. C., da Silva Oliveira, Álvaro, & Vieira de Sales Saraiva, V. (2025). The role of breastfeeding in improving the immune system and preventing respiratory infections in children. Journal of Education, Science and Health – JESH, 5(3), 1–14. https://doi.org/10.52832/jesh.v5i3.551

Issue

Section

REVISÕES DA LITERATURA