Ocular manifestations in infants exposed to the Zika virus: an integrative review
DOI:
10.52832/jesh.v3i1.165Keywords:
Eye, Zika virus, Congenital abnormalitiesAbstract
Zika virus belongs to the Flavivirus genus and is transmitted to humans, mainly by the Aedes aegypti mosquito. The infection is usually asymptomatic, but it can manifest itself with serious repercussions in newborns who had contact with the viral strain during the gestational period. The set of clinical characteristics presented by the children was named Congenital Zika Syndrome, in which microcephaly and visual alterations are quite common. This work aims to verify in the literature the damage caused to the organs of human vision in children exposed to the Zika virus during the gestational period and to establish the pathogenic relationship of this syndrome. This is an integrative review of the literature carried out at the National Library of Health (BVS), at the National Library of Medicine (PubMed) and at Scientific Electronic Library Online (SciElo), using the descriptors: Infecção por Zika vírus, Oftalmopatias, Anormalidades congênitas and their correlates in English. Thirteen articles were chosen for this review. Hypoplasia of the second pair of cranial nerves, choriorectal atrophy, macular scarring, iris coloboma, congenital cataracts, glaucoma and microphthalmia are among the most prevalent ocular lesions in Congenital Zika Syndrome. Despite this link, it is still possible to infer that when the infection occurs in the first half of the gestational period, the risk becomes greater.
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Agrawal, R., Oo, H. H., Balne, P. K., Ng, L., Tong, L., & Leo, Y. S. (2018). Zika Virus and the Eye. Ocular immunology and inflammation, 26(5), 654–659. https://doi.org/10.1080/09273948.2017.1294184 DOI: https://doi.org/10.1080/09273948.2017.1294184
Alpuche-Lazcano, S. P., McCullogh, C. R., Del Corpo, O., Rance, E., Scarborough, R. J., Mouland, A. J., Sagan, S. M., Teixeira, M. M., & Gatignol, A. (2018). Higher Cytopathic Effects of a Zika Virus Brazilian Isolate from Bahia Compared to a Canadian-Imported Thai Strain. Viruses, 10(2), 53. https://doi.org/10.3390/v10020053 DOI: https://doi.org/10.3390/v10020053
Andrade, P. Y. M., Arrais, N. M. R., Maia, C. R. S., Rebouças, S, C. J. S., Garrido, R. J. (2020). Manifestações oculares em crianças com Síndrome Congênita do vírus Zika. Revista de Medicina da UFC, 60(4), 25-31. https://doi.org/10.20513/2447-6595.2020v60n4p25-31 DOI: https://doi.org/10.20513/2447-6595.2020v60n4p25-31
Bandyopadhyay, D., & Hajra, A. (2017). ZIKA virus: A new threat to the eyes. European journal of internal medicine, 44, e9–e10. https://doi.org/10.1016/j.ejim.2017.05.022 DOI: https://doi.org/10.1016/j.ejim.2017.05.022
Baran, L. C. P., Costa, M. F., Vidal, K. S., Damico, F. M., Barboni, M. T. S., Lima, D. S., França, V. C. R. M., Martins, C. M. G., Tabares, H. S., Dias, S. L., Silva, L. A., Decleva, D., Hamer, R. D., Zatz, M., Bertozzi, A. P. A. P., Gazeta, R. E., Passos, S. D., & Ventura, D. F. (2019). Alterations in visual acuity and visual development in infants 1-24 months old either exposed to or infected by Zika virus during gestation, with and without microcephaly. Journal of AAPOS: the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 23(4), 215.e1–215.e7. https://doi.org/10.1016/j.jaapos.2019.03.005 DOI: https://doi.org/10.1016/j.jaapos.2019.03.005
Calle-Giraldo, J. P., Rojas, C. A., Hurtado, I. C., Barco, C., Libreros, D., Sánchez, P. J., López, P., Arias, A., Dávalos, D. M., Lesmes, M. C., Pinzón, E., Ortiz, V. A., & López-Medina, E. (2019). Outcomes of Congenital Zika Virus Infection During an Outbreak in Valle del Cauca, Colombia. The Pediatric infectious disease journal, 38(7), 735–740. https://doi.org/10.1097/INF.0000000000002307 DOI: https://doi.org/10.1097/INF.0000000000002307
Costa, C. B. D. C., & Freitas, D. (2022). Ocular findings of congenital Zika virus infection with microcephaly. International ophthalmology, 42(10), 3117–3127. https://doi.org/10.1007/s10792-022-02311-8 DOI: https://doi.org/10.1007/s10792-022-02311-8
De Paula Freitas, B., de Oliveira Dias, J. R., Prazeres, J., Sacramento, G. A., Ko, A. I., Maia, M., & Belfort, R., Jr (2016). Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA ophthalmology, 134(5), 529–535. https://doi.org/10.1001/jamaophthalmol.2016.0267 DOI: https://doi.org/10.1001/jamaophthalmol.2016.0267
Jürgens, I., & Rey, A. (2018). Ocular findings in patients with microcephaly can suggest presumed congenital zika virus infection. Acta ophthalmologica, 96(4), 423–424. https://doi.org/10.1111/aos.13548 DOI: https://doi.org/10.1111/aos.13548
Lebov, J. F., Arias, J. F., Balmaseda, A., Britt, W., Cordero, J. F., Galvão, L. A., Garces, A. L., Hambidge, K. M., Harris, E., Ko, A., Krebs, N., Marques, E. T. A., Martinez, A. M., McClure, E., Miranda-Filho, D. B., Moreira, M. E. L., Mussi-Pinhata, M. M., Ochoa, T. J., Osorio, J. E., Scalabrin, D. M. F., … Zorrilla, C. (2019). International prospective observational cohort study of Zika in infants and pregnancy (ZIP study): study protocol. BMC pregnancy and childbirth, 19(1), 282. https://doi.org/10.1186/s12884-019-2430-4 DOI: https://doi.org/10.1186/s12884-019-2589-8
Marques, V. M., Santos, C. S., Santiago, I. G., Marques, S. M., Nunes Brasil, M. D. G., Lima, T. T., & Costa, P. S. (2019). Neurological Complications of Congenital Zika Virus Infection. Pediatric neurology, 91, 3–10. https://doi.org/10.1016/j.pediatrneurol.2018.11.003 DOI: https://doi.org/10.1016/j.pediatrneurol.2018.11.003
Massetti, T., Herrero, D., Alencar, J., Silva, T., Moriyama, C., Gehrke, F., Tonks, J., Fonseca, F., Watson, S., Monteiro, C., & Voos, M. (2020). Clinical characteristics of children with congenital Zika syndrome: a case series. Arquivos de neuro-psiquiatria, 78(7), 403–411. https://doi.org/10.1590/0004-282X20200020 DOI: https://doi.org/10.1590/0004-282x20200020
Mendes, K. D. S., Silveira, R. C. C. P., Galvão, C. M. (2019). Use of the bibliographic reference manager in the selection of primary studies in integrative reviews. Texto & Contexto – Enfermagem, 28, e20170204. https://doi.org/10.1590/1980-265X-TCE-2017-0204. DOI: https://doi.org/10.1590/1980-265x-tce-2017-0204
Mercado-Reyes, M., Gilboa, S. M., Valencia, D., Daza, M., Tong, V. T., Galang, R. R., Winfield, C. M., Godfred-Cato, S., Benavides, M., Villanueva, J. M., Thomas, J. D., Daniels, J., Zaki, S., Reagan-Steiner, S., Bhatnagar, J., Schiffer, J., Steward-Clark, E., Ricaldi, J. N., Osorio, J., Sancken, C. L., … Ospina Martinez, M. L. (2021). Pregnancy, Birth, Infant, and Early Childhood Neurodevelopmental Outcomes among a Cohort of Women with Symptoms of Zika Virus Disease during Pregnancy in Three Surveillance Sites, Project Vigilancia de Embarazadas con Zika (VEZ), Colombia, 2016-2018. Tropical medicine and infectious disease, 6(4), 183. https://doi.org/10.3390/tropicalmed6040183 DOI: https://doi.org/10.3390/tropicalmed6040183
Musso, D., & Gubler, D. J. (2016). Zika Virus. Clinical microbiology reviews, 29(3), 487–524. https://doi.org/10.1128/CMR.00072-15 DOI: https://doi.org/10.1128/CMR.00072-15
Ospina, M. L., Tong, V. T., Gonzalez, M., Valencia, D., Mercado, M., Gilboa, S. M., Rodriguez, A. J., Tinker, S. C., Rico, A., Winfield, C. M., Pardo, L., Thomas, J. D., Avila, G., Villanueva, J. M., Gomez, S., Jamieson, D. J., Prieto, F., Meaney-Delman, D., Pacheco, O., & Honein, M. A. (2020). Zika Virus Disease and Pregnancy Outcomes in Colombia. The New England Journal of Medicine, 383(6), 537–545. https://doi.org/10.1056/NEJMoa1911023 DOI: https://doi.org/10.1056/NEJMoa1911023
Paixão, E. S., Rodrigues, M. S., Cardim, L. L., Oliveira, J. F., L C, C., Costa, M. D. C. N., Barreto, M. L., Rodrigues, L. C., Smeeth, L., Andrade, R. F. S., Oliveira, W. K., & Teixeira, M. G. (2019). Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: An interrupted time series analysis. PLoS neglected tropical diseases, 13(9), e0007721. https://doi.org/10.1371/journal.pntd.0007721 DOI: https://doi.org/10.1371/journal.pntd.0007721
Petersen, L. R., Jamieson, D. J., Powers, A. M., & Honein, M. A. (2016). Zika Virus. The New England Journal of Medicine, 374(16), 1552–1563. https://doi.org/10.1056/NEJMra1602113 DOI: https://doi.org/10.1056/NEJMra1602113
Pinazo-Durán, M. D., & Silva, E. D. (2017). Zika virus. A teratogenic agent for the eyes. El virus del Zika. Un agente teratogénico ocular. Archivos de la Sociedad Espanola de Oftalmologia, 92(2), 51–53. https://doi.org/10.1016/j.oftal.2016.11.010 DOI: https://doi.org/10.1016/j.oftal.2016.11.010
Plourde, A. R., & Bloch, E. M. (2016). A Literature Review of Zika Virus. Emerging infectious diseases, 22(7), 1185–1192. https://doi.org/10.3201/eid2207.151990 DOI: https://doi.org/10.3201/eid2207.151990
Roth, N. M., Reynolds, M. R., Lewis, E. L., Woodworth, K. R., Godfred-Cato, S., Delaney, A., Akosa, A., Valencia-Prado, M., Lash, M., Elmore, A., Langlois, P., Khuwaja, S., Tufa, A., Ellis, E. M., Nestoridi, E., Lyu, C., Longcore, N. D., Piccardi, M., Lind, L., Starr, S., … Moore, C. A. (2022). Zika-Associated Birth Defects Reported in Pregnancies with Laboratory Evidence of Confirmed or Possible Zika Virus Infection - U.S. Zika Pregnancy and Infant Registry, December 1, 2015-March 31, 2018. MMWR. Morbidity and mortality weekly report, 71(3), 73–79. https://doi.org/10.15585/mmwr.mm7103a1 DOI: https://doi.org/10.15585/mmwr.mm7103a1
Santos, M. A. R. C., & Galvão, M. G. A. (2014). A elaboração da pergunta adequada de pesquisa. Residência Pediátrica, 4(2):53-56.
Trigueiro, S. A., Neves, B. F., Aguiar, M. S. B., & Araújo, J. S. S. (2019). Correlation between cephalic circumference at birth and ocular alterations in patients with microcephaly potentially associated with Zika Virus infection. Revista da Associação Médica Brasileira, 65(6), 909–913. https://doi.org/10.1590/1806-9282.65.6.909 DOI: https://doi.org/10.1590/1806-9282.65.6.909
Tsui, I., Moreira, M. E. L., Rossetto, J. D., Vasconcelos, Z., Gaw, S. L., Neves, L. M., Zin, O. A., Haefeli, L., Silveira Filho, J. C. B., Gomes, S. C., Jr, Adachi, K., Pone, M. V. D. S., Pone, S. M., Pereira, J. P., Jr, Belfort, R., Arumugaswami, V., Brasil, P., Nielsen-Saines, K., & Zin, A. A. (2018). Eye Findings in Infants With Suspected or Confirmed Antenatal Zika Virus Exposure. Pediatrics, 142(4), e20181104. https://doi.org/10.1542/peds.2018-1104 DOI: https://doi.org/10.1542/peds.2018-1104
Ventura, C. V., Maia, M., Ventura, B. V., Linden, V. V., Araújo, E. B., Ramos, R. C., Rocha, M. A., Carvalho, M. D., Belfort, R., Jr, & Ventura, L. O. (2016). Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arquivos brasileiros de oftalmologia, 79(1), 1–3. https://doi.org/10.5935/0004-2749.20160002 DOI: https://doi.org/10.5935/0004-2749.20160002
Ventura, C. V., Ventura Filho, M. C., & Ventura, L. O. (2019). Ocular Manifestations and Visual Outcome in Children With Congenital Zika Syndrome. Topics in magnetic resonance imaging: TMRI, 28(1), 23–27. https://doi.org/10.1097/RMR.0000000000000192 DOI: https://doi.org/10.1097/RMR.0000000000000192
Ventura, C. V., & Ventura, L. O. (2018). Ophthalmologic Manifestations Associated With Zika Virus Infection. Pediatrics, 141(Suppl 2), S161–S166. https://doi.org/10.1542/peds.2017-2038E DOI: https://doi.org/10.1542/peds.2017-2038E
Ventura, L. O., Ventura, C. V., Dias, N. C., Vilar, I. G., Gois, A. L., Arantes, T. E., Fernandes, L. C., Chiang, M. F., Miller, M. T., & Lawrence, L. (2018). Visual impairment evaluation in 119 children with congenital Zika syndrome. Journal of AAPOS: the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 22(3), 218–222.e1. https://doi.org/10.1016/j.jaapos.2018.01.009 DOI: https://doi.org/10.1016/j.jaapos.2018.01.009
Verçosa, I., Carneiro, P., Verçosa, R., Girão, R., Ribeiro, E. M., Pessoa, A., Almeida, N. G., Verçosa, P., & Tartarella, M. B. (2017). The visual system in infants with microcephaly related to presumed congenital Zika syndrome. Journal of AAPOS: the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 21(4), 300–304.e1. https://doi.org/10.1016/j.jaapos.2017.05.024 DOI: https://doi.org/10.1016/j.jaapos.2017.05.024
Yepez, J. B., Murati, F. A., Pettito, M., Peñaranda, C. F., de Yepez, J., Maestre, G., Arevalo, J. F., & Johns Hopkins Zika Center (2017). Ophthalmic Manifestations of Congenital Zika Syndrome in Colombia and Venezuela. JAMA ophthalmology, 135(5), 440–445. https://doi.org/10.1001/jamaophthalmol.2017.0561 DOI: https://doi.org/10.1001/jamaophthalmol.2017.0561
Zin, A. A., Tsui, I., Rossetto, J., Vasconcelos, Z., Adachi, K., Valderramos, S., Halai, U. A., Pone, M. V. D. S., Pone, S. M., Silveira Filho, J. C. B., Aibe, M. S., da Costa, A. C. C., Zin, O. A., Belfort, R., Jr, Brasil, P., Nielsen-Saines, K., & Moreira, M. E. L. (2017). Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection. JAMA pediatrics, 171(9), 847–854. https://doi.org/10.1001/jamapediatrics.2017.1474 DOI: https://doi.org/10.1001/jamapediatrics.2017.1474
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