ANALYSIS OF THE INTERACTION OF THE CONTAMINANT METHYLMERCURY WITH HEMOGLOBIN FROM THE FISH MATRINXÃBrycon cephalus (GÜNTHER, 1869)

Analysis of the interaction of the contaminant methylmercury with hemoglobin from the fish matrinxã Brycon cephalus (Günther, 1869)

Authors

DOI:

10.52832/jesh.v2i2.132

Keywords:

Contaminantes, Mercúrio, Peixes, Toxicidade

Abstract

Environmental damage due to an unbalanced environment causes problems that are often irreversible for the biota. The increase in population triggers an increase in industrial production and consumption, and often both industries and individuals do not properly dispose of their waste, causing contamination in the air, soil and water. In water, contaminants can undergo the process of bioaccumulation and bimagnification, reaching humans through the consumption of fish, for example. Methylmercury is a toxic form of mercury, being highly polluting and contaminating when in contact with living beings. The objective of this research was to verify the pattern of interaction between methylmercury and hemoglobin in the fish Brycon cephalus through molecular docking. The binding free energy obtained for the hemoglobin-methylmercury complex was -2.0 kcal/mol. Six hemoglobin amino acids were involved in binding to methylmercury, namely: Valine, Serine, Leucine Arginine and Phenyalanine. Molecular docking indicated the tendency of mercury to bind to hemoglobin Brycon cephalus, which can damage metabolism. Thus, new complementary experiments (in vitro and in vivo) should occur to evaluate the possible toxic effect of methylmercury on this species.

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Author Biographies

Eduarda Medran Rangel, Professora na Prefeitura Municipal de Rio Grande, RS, Brasil

Doutora em Ciência e Engenharia de Materiais – Universidade Federal de Pelotas (UFPel). Professora na Prefeitura Municipal de Rio Grande, RS, Brasil.

Estela Fernandes e Silva, Prefeitura Municipal de Rio Grande, RS, Brasil

Doutora Ciências Fisiológicas – Universidade Federal de Rio Grande (FURG). Professora na Prefeitura Municipal de Rio Grande, RS, Brasil.

Daiana Kaster Garcez, Professora na Prefeitura Municipal de Rio Grande, RS, Brasil

Doutora em Biologia de Ambientes Aquáticos Continentais – Universidade Federal de Rio Grande (FURG). Professora na Prefeitura Municipal de Rio Grande, RS, Brasil.

Karine Laste Macagnan, Professora na Prefeitura Municipal de Rio Grande, RS, Brasil.

Doutora em Ciências – Universidade Federal de Pelotas (UFPel). Professora na Prefeitura Municipal de Rio Grande, RS, Brasil

Adrize Medran Rangel, Universidade de Franca (UNIFRAN)

Licenciada em Ciências Biológicas – Universidade de Franca (UNIFRAN). Líder da Planta de Fertilizantes - JOSAPAR, Pelotas, RS, Brasil.

Louise Vargas Ribeiro, rofessora na Prefeitura Municipal de Arroio do Padre, RS, Brasil

Doutora em Agronomia – Universidade Federal de Pelotas (UFPel). Professora na Prefeitura Municipal de Arroio do Padre, RS, Brasil

Paula Fernandes e Silva, Universidade Federal de Pelotas (UFPel)

Cirurgiã-dentista – Universidade Federal de Pelotas (UFPel). Mestranda na área de Dentística e Cariologia (UFPel), RS, Brasil.

Tainã Figueiredo Cardoso, Embrapa Pecuária Sudeste - São Carlos, SP, Brasil

Doutora em Producción Animal pela Universitat Autònoma de Barcelona. Pós-doutoranda pela Embrapa Pecuária Sudeste - São Carlos, SP, Brasil.

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Published

16/04/2022

How to Cite

Medran Rangel, E., Fernandes e Silva, E. ., Kaster Garcez, D., Laste Macagnan, K. ., Medran Rangel, A., Vargas Ribeiro, L., Fernandes e Silva, P. ., & Figueiredo Cardoso, T. . (2022). ANALYSIS OF THE INTERACTION OF THE CONTAMINANT METHYLMERCURY WITH HEMOGLOBIN FROM THE FISH MATRINXÃBrycon cephalus (GÜNTHER, 1869): Analysis of the interaction of the contaminant methylmercury with hemoglobin from the fish matrinxã Brycon cephalus (Günther, 1869). Journal of Education, Science and Health – JESH, 2(2), 1–6. https://doi.org/10.52832/jesh.v2i2.132

Issue

Vol. 2 No. 2 (2022): JESH

Section

CIÊNCIAS BIOLÓGICAS

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