Eventos oxidativos relacionados à angiotensina II e angiotensina 1-7 na hipertensão: uma revisão de estudos pré-clínicos

Matheus Vinicius Barbosa da Silva; Alice Fernandes Von Den Steinen; Fátima Beatriz da Costa Santos; Beatriz da Silva Salvador; Heverton Valentim Colaço da Silva

doi:10.52832/jormed.v2.452

Authors

Matheus Vinicius Barbosa da Silva Universidade Federal de Pernambuco https://orcid.org/0000-0003-1295-6301
Alice Fernandes Von Den Steinen Afya Faculdade de Ciências Médicas de Jaboatão https://orcid.org/0009-0000-3960-6745
Fátima Beatriz da Costa Santos Universidade Federal de Pernambuco https://orcid.org/0000-0003-4286-3026
Beatriz da Silva Salvador Universidade de Pernambuco https://orcid.org/0000-0001-9319-5326
Heverton Valentim Colaço da Silva Universidade Federal de Pernambuco https://orcid.org/0000-0001-7169-4140

DOI:

10.52832/jormed.v2.452

Abstract

Upregulation of the renin-angiotensin-aldosterone system and oxidative stress are among the main events related to the pathogenesis and pathophysiology of hypertension. In the renin-angiotensin system, specifically Angiotensin II and the recently discovered Angiotensin-(1-7), are important modulators of the redox state. In this sense, the objective of this study was to describe the effects promoted by Angiotensin II and Angiotensin 1-7 on oxidative parameters and the implications for blood pressure. This is a review study, developed in the PubMed, SciELO and ScienceDirect databases. The important relationship between the classical arm of the system, specifically related to the interaction between angiotensin-II and angiotensin receptor subtype I and the development of oxidative stress, is highlighted. Conversely, Angiotensin-(1-7) with opposite effects on this side of the system is highlighted. Thus, the importance of an approach aimed at this protective side of the system is observed, which appears to be a future therapeutic target for the treatment of hypertension.

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Oxidative events related to angiotensin II and angiotensin 1-7 in hypertension

a review of preclinical studies

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