Eventos oxidativos relacionados à angiotensina II e angiotensina 1-7 na hipertensão
uma revisão de estudos pré-clínicos
DOI:
10.52832/jormed.v2.452Resumen
A supra regulação do sistema renina-angiotensina-aldosterona e o estresse oxidativo estão entre principais eventos relacionados a patogênese e fisiopatologia da HAS. No sistema renina-angiotensina, em específico a Angiotensina II e a recentemente descoberta Angiotensina-(1-7), apresentam-se como importantes moduladores do estado redox. Neste sentido, o objetivo deste estudo foi descrever os efeitos promovidos pela Angiotensina II e Angiotensina 1-7 sobre parâmetros oxidativos e as implicações sobre a pressão arterial. Trata-se de um estudo de revisão, desenvolvido nas bases de dados PubMed, SciELO e ScienceDirect. Destaca-se a importante relação entre o braço clássico do sistema, especificamente relacionado a interação entre a angiotensina-II e receptor de angiotensina de subtipo I e o desenvolvimento de estresse oxidativo. De forma contrária destacando a Angiotensina-(1-7) com efeitos opostos a esse lado do sistema. Dessa forma, observa-se a importância da abordagem direcionada para este lado protetor do sistema, o qual mostra-se como um futuro alvo terapêutico para o tratamento da hipertensão.
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