Immunohistochemistry in Breast Cancer Diagnosis: Main Protein Markers

Authors

DOI:

10.52832/jormed.v2.433

Keywords:

Breast cancer, Immunohistochemistry, HER2 protein.

Abstract

Introduction: Breast cancer (BC) is a malignant neoplasm that has a considerable impact on women's lives and is one of the main causes of mortality among women. Its prevalence and severity highlight the importance of ongoing research to deepen our understanding of this disease. Objective: To explore the role of immunohistochemistry as an essential tool in the diagnosis and prognostic evaluation of CM. Methods: This is a literature review using scientific articles from the US National Library of Medicine (PubMed) and Scientific Electronic Library Online (SciELO) databases. To identify the relevant studies, descriptors from DeCS (Health Sciences Descriptors) were used with the Boolean operator “AND”, including the terms “Breast cancer”, “Immunohistochemistry” and “HER2+ protein”. Free full texts, published in peer-reviewed journals, available in English and Portuguese, and studies published between 2019 and 2023. Studies that were not directly related to the proposed topic were excluded from the analysis. Results: Immunohistochemistry demonstrates efficacy in accurately detecting the HER2+ protein in breast cancer, and is essential for assessing prognostic factors and differentiating lesions in breast tissue. Its ability to reliably identify the protein and discriminate between different types of BC contributes to a more precise and personalized therapeutic approach, improving patients' clinical outcomes. Conclusion: Immunohistochemistry is crucial in the diagnosis and understanding of breast cancer. In addition to confirming the diagnosis, it identifies the presence of HER2+ and other markers, influencing therapeutic and prognostic decisions. This personalized approach promotes more effective treatment, highlighting the importance of immunohistochemistry in the management of BC.

Author Biographies

Victor Hugo Patuci da Silva, Centro Universitário Nossa Senhora do Patrocínio (CEUNSP)

Graduando em Biomedicina, Centro Universitário Nossa Senhora do Patrocínio (CEUNSP), Itu-SP, Brasil

Tereza Raquel Xavier Viana, Universidade Federal de São Paulo (UNIFESP), Faculdade de Medicina de Jundiaí (FMJ) e Centro Universitário Nossa Senhora do Patrocínio (Ceunsp)

Mestranda em Ciências da Saúde na Faculdade de Medicina de Jundiaí (FMJ), com previsão de conclusão em 2025. Graduada em Gestão de Marketing pela Universidade Nove de Julho (UNINOVE), com pós-graduação em Neurociências pela Faculdade Venda Nova do Imigrante (Faveni), e especializações em Cannabis Medicinal pela Doane University (EUA), e Auditoria em Sistemas de Saúde e Administração Hospitalar pela Faculdade de São Marcos (FACSM). Cursando uma segunda especialização em Neurociências pela Universidade Federal de São Paulo (UNIFESP) e Gerontologia pelo Centro Universitário Internacional (UNINTER), com conclusão prevista em 2024. Simultaneamente, busca segunda graduação em Biomedicina no Centro Universitário Nossa Senhora do Patrocínio (CEUNSP - ITU), com término previsto para 2025. Além disso, possui extensão em Neuroanatomia pela Universidade de São Paulo (FMRP-USP). Associada à Sociedade Brasileira de Neurociências e Comportamento (SBNeC), com filiação à FeSBE, SBPC, IBRO e FALAN, bem como à Sociedade Brasileira de Geriatria e Gerontologia (SBGG).

Juliana Isquierdo Miron, Centro Universitário Nossa Senhora do Patrocínio (CEUNSP)

Graduanda em Biomedicina, Centro Universitário Nossa Senhora do Patrocínio (CEUNSP), Itu-SP, Brasil

Regiane Priscila Ratti, Centro Universitário Nossa Senhora do Patrocínio (CEUNSP), Itu-SP

Doutora em Biotecnologia, Universidade Federal de São Carlos (UFSCAR). Docente do Centro Universitário Nossa Senhora do Patrocínio (CEUNSP), Itu-SP, Brasil.

Larissa Teodoro Rabi, Centro Universitário Nossa Senhora do Patrocínio (CEUNSP)

Biomédica habilitada em Biologia Molecular, Análises Clínicas, Hematologia, Imunologia e Citologia Oncótica. Mestre em Ciências pelo Departamento de Clínica Médica da Universidade Estadual de Campinas (UNICAMP). Docente do Curso de Biomedicina do Centro Universitário Nossa Senhora do Patrocínio (CEUNSP/Cruzeiro do Sul).

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Published

2024-06-16

How to Cite

Silva, V. H. P. da, Viana, T. R. X., Miron, J. I., Ratti, R. P., & Rabi, L. T. (2024). Immunohistochemistry in Breast Cancer Diagnosis: Main Protein Markers. Journal of Research in Medicine and Health, 2. https://doi.org/10.52832/jormed.v2.433

Issue

Vol. 2 (2024): JORMED

Section

Original Article Medical and Health Sciences

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